Targeting the P2X7 receptor reduces harmful human brain inflammation

Science Daily Exercise reported that researchers have identified a new strategy to reduce harmful brain inflammation by targeting a receptor known as P2X7. Blocking this receptor significantly reduced inflammation in human brain tissue, according to study findings published in the journal Brain. Professor Nicholas Barnes at the University of Birmingham led the research team. [1]

The discovery shows that scientists may be able to repurpose existing drugs that already block the P2X7 receptor. Science Daily Exercise reported that this therapeutic approach could target conditions such as traumatic brain injury, Alzheimer's disease, Parkinson's disease, depression, and schizophrenia. [1]

Alzheimer's disease is a neurodegenerative disorder that represents the most common cause of dementia, accounting for roughly 60% to 70% of cases. The condition leads to progressive memory loss, behavioral changes, and the loss of bodily functions. [3]

Medical treatments for related chronic neurological disorders also include therapies such as deep brain stimulation. That surgical treatment uses an implanted pulse generator in the chest to send controlled electrical impulses to dysfunctional circuits in the brain. [4]